CBG is often referenced as “the mother of all cannabinoids” because of its acidic precursor – CBGA. CBG was first isolated in 1964 and then synthesized in 1971, so there is nothing new here other than education. It is also the precursor of all cannabinoids such as tetrahydrocannabinol (THC), cannabidiol (CBD), and many other cannabinoids present in the cannabis plant. The plant will begin to mature, and most of its CBGA is converted into other molecules, which then leaves very low levels of CBG in the final product which is the mature, dried flower. Most are below 1% by dry weight. Unless you are growing specially bred strains, which can produce close to 20% CBG. OF course, when this occurs there is little THC.
More recent preclinical research has shown that this versatile, nonintoxicating compound is a weak partial agonist or activator of the cannabinoid receptors CB1 and CB2, an antagonist of the serotonin 1A receptor, and an agonist of the inhibitory neurotransmitter GABA. It’s also a PPARy agonist and the only known cannabinoid to function as an agonist at the alpha-2 adrenergic receptor. Let's move past the scientific techy stuff.
CBG’s unique and promising pharmacology is creating intrigue which is creating many more reviews and research. Research into its effects on humans has been relatively minimal. As recently as a few years ago, CBG-dominant cannabis varietals were almost unheard of, and any producers that wanted the compound could not easily access it. Lokahi Leaf has been producing CBG for its customers and is available on the website as a standard staple. One of the many benefits is that Lokahi Leaf is a grower, and has been scientifically intrigued by the many uses of cannabinoids for a very long time.
It has seen CBG help treat anxiety and pain, including in individuals for whom CBD wasn’t effective or only worked at too high of a dose to be affordable.
This product sells out fast!
Lokahi Leaf offers 1000mg Mint Flavored option for $129.99 but often on sale for $89.99. Veterans can utilize the contact form and request a regular discount for that price throughout the year. The goal is to provide healing and live a quality life. PAIN FREE!
For further information here are some additional research and articles.
Gaoni Y, Mechoulam R. The structure and function of cannabigerol, a new hashish constituent. Proc Chem Soc. 1964;1:82
Gaoni Y, Mechoulam R. The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish. J Am Chem Soc. 1971;93:217–224.
Nachnani, Rahul et al. “The Pharmacological Case for Cannabigerol.” The Journal of pharmacology and experimental therapeutics vol. 376,2 (2021): 204-212. doi:10.1124/jpet.120.000340
Jastrząb, Anna et al. “The Origin and Biomedical Relevance of Cannabigerol.” International journal of molecular sciences vol. 23,14 7929. 19 Jul. 2022, doi:10.3390/ijms23147929
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